PhD student Experimental Urology / Human Genetics | Radboud University Medical Centre

The PhD student will design and perform molecular epigenetic, genetic and molecular biological research aiming to unravel the mechanism of transcription deregulation in prostate cancer.

- Applies the latest technology in transcriptomics and (epi)genomics including next-generation sequencing, chromatin immunoprecipitation and DNA methylation analysis.

- Investigates newly discovered transcriptional defects in tumor cell lines and clinical samples.

- Performs functional studies to reveal the role of transcription in changing the epigenetic landscape and in prostate tumor initiation and progression.

Profile

- MSc in molecular biology, biochemistry or molecular life sciences

- Experience with tissue culture, epigenetic assays and data analysis is strongly recommended

- Experience in molecular biology or molecular genetics

- Affinity with large dataset analysis and bioinformatics is required

- Strongly motivated to perform scientific research

Organization

The department of Urology is an independent unit within the Radboud university medical centre (Nijmegen), and offers top clinical care. As a member of the Research Institute for Oncology, the department aims to advance innovation in translational research in oncology and to reduce the morbidity and mortality of cancer. In collaboration with researchers from several disciplines, we are unraveling the biology of tumors and develop new diagnostics and therapies. Our group consists of molecular and cell biologists, immunologists and urologists. Our team conducts research on urological malignancies, prostate and bladder cancer in particular, since the late 1980s, and is recognized internationally for its expertise in this field.

The department of Human Genetics provides counseling and diagnostics for patients with inherited and acquired diseases. The research groups perform cutting-edge studies to investigate the relationship between genes and diseases, in particular cancer, deafness, blindness, mental retardation, and congenital abnormalities. State-of-the-art facilities are available for sequence-, genescan-, linkage-, and microarray analyses.

This PhD project is a part of an ongoing collaboration between both departments and the PhD student will be under direct supervision of Dr. Marcel Coolen (Human Genetics) and co-supervised by Prof. Dr. Jack Schalken (Experimental Urology).

Comments and contact information

Appointment will initially be for 1 year. In case of adequate performance the contract will be prolonged by 3 years resulting in to a total appointment of 4 years.

For more information you can contact Dr. Marcel Coolen, group leader, +31 (0) 24 361 04 87, Αυτή η διεύθυνση Email προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε. (Use this email address only for information. For application use the Apply button)

Closing date 21-10-2013